• Research Themes
• Accomplishments
• Publications

Accomplishments

Highlighted below are examples of previous relevant work and accomplishments by our mentors and their trainees.

A landmark study published in September 2008 evaluated the effectiveness of arthroscopic surgery for osteoarthritis of the knee (N Engl J Med 359: 1097, 2008, publication 2). Surprisingly, surgery provided no additional benefit to optimal physical and medical therapy. This research will have tremendous impact on clinical practice and health care costs across Canada and around the world.

Research carried out by the Canadian Centre for Activity and Aging has helped promote exercise by the elderly, measurably improving the health and mobility of thousands with considerable impact on health policies across Canada.

Protons were found to act directly on osteoclasts to stimulate bone resorption (Proc Natl Acad Sci USA 102: 2643, 2005, publication 15). This resolved the 80-year-old medical mystery of how acid causes bone loss and opened the way for new antiresorptive therapies. This discovery led to a patent application and collaboration with Novartis.

JuMP mentors collaborate extensively through partnerships including: the CIHR Group in Skeletal Development and Remodeling; Canadian Arthritis Network NCE; Emerging Materials Knowledge Network, a Provincial Centres of Excellence; the New Emerging Team "Molecular mechanisms of pain and fatigue in osteoarthritis"; and the Ontario Consortium for Small Animal Imaging.