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David Holdsworth

Dr. David Holdsworth is the Dr. Sandy Kirkley Chair in Musculoskeletal Research and a Professor in the Departments of Surgery and Medical Biophysics in the Schulich School of Medicine and Dentistry, at the University of Western Ontario. He is also a Scientist in the Imaging group at the Robarts Research Institute.

His research program involves the development and use of advanced CT, MRI, and ultrasound techniques to investigate vascular disease and musculoskeletal disease. With respect to vascular disease, Dr. Holdsworth has previously been supported as a Career Investigator with the Heart and Stroke Foundation of Ontario, with funding to investigate the use of advanced Doppler ultrasound techniques to characterize diseased blood vessels leading to the brain. For the past several years, musculoskeletal imaging has been a major focus of Dr. Holdsworth's research program, with projects ranging from basic skeletal research to clinical therapy. This program involves investigators who specialize in the areas of osteoporosis, osteoarthritis, and rheumatoid arthritis. Dr. Holdsworth and his team have developed new methods for musculoskeletal disease detection and treatment, for both basic pre-clinical and clinical applications. With assistance from collaborators at The University of Western Ontario, and across the country, Dr. Holdsworth has developed new micro-CT techniques that have been applied to a variety of animal models including rabbits, rats and mice. With collaborators Dr. Naudie and Dr. Dunning, he has been funded by CIHR for five years to develop new techniques to image the interface between bones and metal implants, and to develop new techniques for dynamic radiostereometric analysis following joint replacement.

With respect to commercialization and technology transfer, Dr. Holdsworth was a Founding Scientist of Enhanced Vision Systems, Corp., which was purchased by General Electric Medical Systems in November 2002.